The best topical treatment depends on plaque thickness, body location, age, severity, and whether you need short-term flare control or long-term maintenance. Medical note: Psoriasis is a chronic immune-mediated disease. This article explains commonly used U.S. topical options, but it cannot tell you which prescription strength is safe for your skin. Face, groin, skin folds, children, pregnancy, large body areas, and severe flares need extra care. If you are standing in a U.S. drugstore wondering…